Article
Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci.
Annals of human genetics - 1 Nov 1999
Hallman D M, Groenemeijer B E, Jukema J W, Boerwinkle E, Kastelein J J
Abstract excerpt
Simultaneously analysing genotype effects at several closely-linked loci may be preferable to analysing them separately, but can be difficult, due to multiple genotype classes, small class sizes, and non-independence induced by associations among loci. Analysis of haplotype effects offers an alternative approach. We studied effects of haplotypes comprising 3 loci (5' to 3': PvuII, HindIII, and Ser 447 -Stop) in...
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