Article
Use of haplotype information to test involvement of the LRP gene in Alzheimer's disease in the French population.
European journal of human genetics : EJHG - 1 Jun 2001
Verpillat P, Bouley S, Campion D, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Antérion C, Agid Y, Brice A, Clerget-Darpoux F
Abstract excerpt
The low density lipoprotein receptor-related protein gene (LRP) is a good candidate gene for Alzheimer's Disease (AD). Its protein is involved in the physiopathology of AD and has been found in senile plaques; on the other hand, LRP is located in 12q, a region in which genetic linkage to AD was reported. Two common polymorphisms, a tetranucleotide repeat in the 5' untranslated region and a single nucleotide...
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