Article
Epicutaneous immunization with DNP-BSA induces CD4+ CD25+ Treg cells that inhibit Tc1-mediated CS.
Immunology and cell biology - 1 Sept 2012
Majewska-Szczepanik Monika, Zemelka-Wiącek Magdalena, Ptak Włodzimierz, Wen Li, Szczepanik Marian
Abstract excerpt
As we have shown previously that protein antigen applied epicutaneously (EC) in mice inhibits TNP-specific Th1-mediated contact sensitivity (CS), we postulated that the maneuver of EC immunization might also suppress Tc1-dependent CS response. Here we showed that EC immunization of normal mice with 2,4-dinitrophenylated bovine serum albumin (DNP-BSA) applied on the skin in the form of a patch induces a state of...
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