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Article

Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus.

The Journal of clinical investigation - 1 Jul 2003

Kupferwasser Leon Iri, Yeaman Michael R, Nast Cynthia C, Kupferwasser Deborah, Xiong Yan-Qiong, Palma Marco, Cheung Ambrose L, Bayer Arnold S

Abstract excerpt

Aspirin has been previously shown to reduce the in vivo virulence of Staphylococcus aureus in experimental endocarditis, through antiplatelet and antimicrobial mechanisms. In the present study, salicylic acid, the major in vivo metabolite of aspirin, mitigated two important virulence phenotypes in both clinical and laboratory S. aureus strains: alpha-hemolysin secretion and fibronectin binding in vitro. In...

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Identifiers

PMID: 12865410
DOI: 10.1172/JCI16876
PMCID: PMC164286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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