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Article

Fibrinogen depletion attenuates Staphyloccocus aureus infection by preventing density-dependent virulence gene up-regulation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2003

Rothfork Jacob M, Dessus-Babus Sophie, Van Wamel Willem J B, Cheung Ambrose L, Gresham Hattie D

Abstract excerpt

Staphylococcus aureus undergoes a density-dependent conversion in phenotype from tissue-adhering to tissue-damaging and phagocyte-evading that is mediated in part by the quorum-sensing operon, agr, and its effector, RNAIII. Contributions of host factors to this mechanism for regulating virulence have not been studied. We hypothesized that fibrinogen, as a component of the inflammatory response, could create...

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Source

Identifiers

PMID: 14607942
DOI: 10.4049/jimmunol.171.10.5389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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