Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis.

doi:10.1172/JCI117530

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Article

Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis.

The Journal of clinical investigation - 1 Nov 1994

Cheung A L, Eberhardt K J, Chung E, Yeaman M R, Sullam P M, Ramos M, Bayer A S

Abstract excerpt

Microbial pathogenicity in Staphylococcus aureus is a complex process involving a number of virulence genes that are regulated by global regulatory systems including sar and agr. To evaluate the roles of these two loci in virulence, we constructed sar-/agr- mutants of strains RN6390 and RN450 and...

Topics

Animals
Bacterial Adhesion
Disease Models, Animal
Endocarditis, Bacterial
Genes, Bacterial
Mutation
Phenotype
Rabbits
Staphylococcus aureus
Virulence

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