Article
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Molecular cell - 1 Nov 2000
Durocher D, Taylor I A, Sarbassova D, Haire L F, Westcott S L, Jackson S P, Smerdon S J, Yaffe M B
Abstract excerpt
Forkhead-associated (FHA) domains are a class of ubiquitous signaling modules that appear to function through interactions with phosphorylated target molecules. We have used oriented peptide library screening to determine the optimal phosphopeptide binding motifs recognized by several FHA domains, including those within a number of DNA damage checkpoint kinases, and determined the X-ray structure of Rad53p-FHA1,...
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