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The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome

12 Jan 2008

Abstract excerpt

BACKGROUND: Polycystic ovary syndrome (PCOS) may be programmed in utero by androgen excess. Our aim was to examine the role of the sex hormone-binding globulin (SHBG) and androgen receptor (AR) gene polymorphisms, in the phenotypic expression of PCOS. METHODS: A cohort of 180 women with PCOS and 168 healthy women of reproductive age were investigated. BMI was recorded and the hormonal profile was determined on...

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PMID: 18192296
DOI: 10.1093/humrep/dem382

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