Article
Androgen receptor CAG repeats length polymorphism and the risk of polycystic ovarian syndrome (PCOS).
PloS one - 1 Jan 2013
Rajender Singh, Carlus Silas Justin, Bansal Sandeep Kumar, Negi Mahendra Pal Singh, Negi Mahendra Pratap Singh, Sadasivam Nirmala, Sadasivam Muthusamy Narayanan, Thangaraj Kumarasamy
Abstract excerpt
OBJECTIVE: Polycystic ovarian syndrome (PCOS) refers to an inheritable androgen excess disorder characterized by multiple small follicles located at the ovarian periphery. Hyperandrogenism in PCOS, and inverse correlation between androgen receptor (AR) CAG numbers and AR function, led us to hypothesize that CAG length variations may affect PCOS risk. METHODS: CAG repeat region of 169 patients recruited following...
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