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Article

A transcription map of the 6p22.3 reading disability locus identifying candidate genes.

BMC genomics - 30 Jun 2003

Londin Eric R, Meng Haiying, Gruen Jeffrey R

Abstract excerpt

BACKGROUND: Reading disability (RD) is a common syndrome with a large genetic component. Chromosome 6 has been identified in several linkage studies as playing a significant role. A more recent study identified a peak of transmission disequilibrium to marker JA04 (G72384) on chromosome 6p22.3, suggesting that a gene is located near this marker. RESULTS: In silico cloning was used to identify possible candidate...

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Share to Chromosome Mapping
Share to Chromosomes, Human, Pair 6
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dyslexia

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Share to Linkage Disequilibrium

Share to Reverse Transcriptase Polymerase Chain Reaction

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Source

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Identifiers

PMID: 12834540
DOI: 10.1186/1471-2164-4-25
PMCID: PMC166143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A transcription map of the 6p22.3 reading disability locus identifying candidate genes.PMID 12834540Read ↗

Peaks of linkage are localized by a BAC/PAC contig of the 6p reading disability locus.Semantic proximity Read ↗

A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression.Semantic proximity Read ↗

Evidence for linkage and association with reading disability on 6p21.3-22.Semantic proximity Read ↗

A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States.Semantic proximity Read ↗

Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319.Semantic proximity Read ↗

DCDC2 is associated with reading disability and modulates neuronal development in the brain.Semantic proximity Read ↗

Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.Semantic proximity Read ↗

Quantitative trait locus for reading disability on chromosome 6.Semantic proximity Read ↗

Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment.Semantic proximity Read ↗

A dyslexia-associated variant in DCDC2 changes gene expression.Semantic proximity Read ↗

Fine mapping of autosomal dominant nonsyndromic hearing impairment DFNA21 to chromosome 6p24.1-22.3.Semantic proximity Read ↗

Genetic variation in the KIAA0319 5' region as a possible contributor to dyslexia.Semantic proximity Read ↗

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