Article
A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States.
American journal of human genetics - 1 Dec 2004
Francks Clyde, Paracchini Silvia, Smith Shelley D, Richardson Alex J, Scerri Tom S, Cardon Lon R, Marlow Angela J, MacPhie I Laurence, Walter Janet, Pennington Bruce F, Fisher Simon E, Olson Richard K, DeFries John C, Stein John F, Monaco Anthony P
Abstract excerpt
Several quantitative trait loci (QTLs) that influence developmental dyslexia (reading disability [RD]) have been mapped to chromosome regions by linkage analysis. The most consistently replicated area of linkage is on chromosome 6p23-21.3. We used association analysis in 223 siblings from the United Kingdom to identify an underlying QTL on 6p22.2. Our association study implicates a 77-kb region spanning the gene...
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