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Article

A dyslexia-associated variant in DCDC2 changes gene expression.

Behavior genetics - 1 Jan 2011

Meng Haiying, Powers Natalie R, Tang Ling, Cope Natalie A, Zhang Ping-Xia, Fuleihan Ramsay, Gibson Christopher, Page Grier P, Gruen Jeffrey R

Abstract excerpt

Reading disability (RD) or dyslexia is a common neurogenetic disorder. Two genes, KIAA0319 and DCDC2, have been identified by association studies of the DYX2 locus on 6p21.3. We previously identified a 2445 bp deletion, and a compound STR within the deleted region (BV677278), in intron 2 of DCDC2...

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Share to Chromosome Deletion
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Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Share to Regulatory Sequences, Nucleic Acid

Source

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Identifiers

PMID: 21042874
DOI: 10.1007/s10519-010-9408-3
PMCID: PMC3053575

Genes

DCDC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21042874-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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A dyslexia-associated variant in DCDC2 changes gene expression.PMID 21042874Read ↗

DCDC2 is associated with reading disability and modulates neuronal development in the brain.Semantic proximity Read ↗

Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment.Semantic proximity Read ↗

Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.Semantic proximity Read ↗

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The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation.Semantic proximity Read ↗

Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population.Semantic proximity Read ↗

Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population.Semantic proximity Read ↗

A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.Semantic proximity Read ↗

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