Article
DCDC2 is associated with reading disability and modulates neuronal development in the brain.
Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2005
Meng Haiying, Smith Shelley D, Hager Karl, Held Matthew, Liu Jonathan, Olson Richard K, Pennington Bruce F, DeFries John C, Gelernter Joel, O'Reilly-Pol Thomas, Somlo Stefan, Skudlarski Pawel, Shaywitz Sally E, Shaywitz Bennett A, Marchione Karen, Wang Yu, Paramasivam Murugan, LoTurco Joseph J, Page Grier P, Gruen Jeffrey R
Abstract excerpt
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2. Alleles of this compound repeat are in significant disequilibrium with multiple reading...
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