Article
Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.
Molecular psychiatry - 1 Feb 2003
Turic D, Robinson L, Duke M, Morris D W, Webb V, Hamshere M, Milham C, Hopkin E, Pound K, Fernando S, Grierson A, Easton M, Williams N, Van Den Bree M, Chowdhury R, Gruen J, Stevenson J, Krawczak M, Owen M J, O'Donovan M C, Williams J
Abstract excerpt
Linkage disequilibrium (LD) mapping was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3-22. Using a two-stage approach, we tested for association between RD and 22 microsatellite markers in two independent samples of 101 (Stage 1) and 77 (Stage 2) parent/proband trios in which RD was rigorously defined. The most significant replicated associations were...
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