Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis.

doi:10.1371/journal.ppat.1014566

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Article

Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis.

PLoS pathogens - 1 Sept 2026

Arya Deepak, Tormanen Kati, Oh Jay J, Wang Shaohui, Ghiasi Homayon

Abstract excerpt

Herpes simplex virus 1 (HSV‑1) establishes infection through coordinated interactions of multiple viral glycoproteins with host cell receptors. Interactions between the viral glycoprotein D (gD) and the immunomodulatory cellular receptor HVEM (herpesvirus entry mediator) critically influence HSV‑1 latency and reactivation by regulating both receptor engagement and immunomodulatory signaling in the corneal...

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Topics

Receptors, Tumor Necrosis Factor, Member 14
Virus Replication
Herpesvirus 1, Human
Humans
Animals
Viral Envelope Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chlorocebus aethiops

Homeostasis

Protein Binding

Vero Cells

Receptors, Virus

Mutation

Herpes Simplex

Source

Open in PubMed Open full text

Identifiers

PMID: 42709876
DOI: 10.1371/journal.ppat.1014566
PMCID: PMC13581205

Genes

BTLA
CD160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis.PMID 42709876Read ↗

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