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Article

Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2003

Dhanvantari Savita, Shen Fu-Sheng, Adams Tiffany, Snell Christopher R, Zhang ChunFa, Mackin Robert B, Morris Stephen J, Loh Y Peng

Abstract excerpt

In familial hyperproinsulinemia, specific mutations in the proinsulin gene are linked with a profound increase in circulating plasma proinsulin levels. However, the molecular and cellular basis for this disease remains uncharacterized. Here we investigated how these mutations may disrupt the sort...

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Identifiers

PMID: 12829804
DOI: 10.1210/me.2002-0380

Genes

CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12829804-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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