Article
Stratified organization of the nicotinic acetylcholine receptor channel.
Neuroreport - 1 Nov 1992
Devillers-Thiéry A, Galzi J L, Bertrand S, Changeux J P, Bertrand D
Abstract excerpt
Mutations of leucine 247 within the M2 channel domain of the alpha 7 neuronal nicotinic receptor, confer electrophysiological and pharmacological properties, which allow one of the desensitized states to become conductive. Here we show that, in Xenopus oocytes, the effects of the mutations were preserved when 1,2-bis(2-aminophenoxy)-ethane N,N,N',N'-tetraacetic acid (BAPTA) was injected in the cytoplasm to block...
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