Article
SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene.
Experimental dermatology - 1 Jun 2003
Chang Y T, Tsai S F, Lin M W, Liu H N, Lee D D, Shiao Y M, Chin P J, Wang W J
Abstract excerpt
Although genetics analyses have identified the HLA-Cw6 allele to be the major risk allele for psoriasis vulgaris (PV) in many racial groups, it has been proposed that other putative genes near the HLA-C locus are involved in PV susceptibility and that the association of Cw6 is a result of linkage disequilibrium. The SPR1 gene, a predicted gene located 128 kb telomeric to the HLA-C locus, is considered to be one...
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