Article
Modulation of the onset age in primary dystonia by APOE genotype.
Neurology - 24 Jun 2003
Matsumoto S, Nishimura M, Sakamoto T, Asanuma K, Izumi Y, Shibasaki H, Kamatani N, Nakamura T, Kaji R
Abstract excerpt
APOE polymorphisms were studied in 200 unrelated patients with primary dystonia as well as 300 age-matched control subjects. Although no difference was found in APOE genotype between the patients with dystonia and the controls, APOE-epsilon4 carriers developed the disease on average approximately 10 years earlier than APOE-epsilon4 noncarriers (p = 0.0012). This suggests that APOE-epsilon4 genotype affects the...
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