Article
Rsp5-Bul1/2 complex is necessary for the HSE-mediated gene expression in budding yeast.
Biochemical and biophysical research communications - 11 Jul 2003
Kaida Daisuke, Toh-e Akio, Kikuchi Yoshiko
Abstract excerpt
Rsp5 is an essential ubiquitin ligase in Saccharomyces cerevisiae and is concerned with many functions such as endocytosis and transcription through ubiquitination of various substrates. Bul1 or its homologue Bul2 binds to Rsp5 through the PY-motif and the bul1 bul2 double mutant is sensitive to various stresses. We demonstrate here that heat shock element (HSE)-mediated gene expression was defective in both...
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