Article
Truncated Bcl-2, a potential pre-metastatic marker in prostate cancer.
Biochemical and biophysical research communications - 11 Jul 2003
Huang Jen-Ming, Lin Tsen-Yin, Chang Donald, Lin Shi-Lung, Ying Shao-Yao
Abstract excerpt
A novel truncated form of Bcl-2, termed Bcl-2psi, was discovered in invasive prostate cancer cells, using laser capture microdissection, RNA-polymerase cycling reaction, and microarray analysis. The expression of Bcl-2psi increased prior to metastasis in higher-grade prostate cancer. The immunoreactive Bcl-2psi was specifically identified in higher-grade prostate cancer cells. These findings suggest that Bcl-2psi...
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