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Article

Prognostic relevance of Bcl‐2 overexpression in surgically treated prostate cancer is not caused by increased copy number or translocation of the gene

24 Oct 2011

Abstract excerpt

BACKGROUND: Overexpression of anti-apoptotic Bcl-2 plays a role in prostate cancer progression, particularly in transformation to androgen-independent disease. Androgen-independent prostate cancers have been shown to harbor Bcl-2 gene copy number gains frequently suggesting that this genetic alteration might play a role in Bcl-2 overexpression. The relation of Bcl-2 overexpression and copy number gains or...

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PMID: 22024950
DOI: 10.1002/pros.21504

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