Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemosensitization of Prostate Cancer by Modulating Bcl-2 Family Proteins

24 Apr 2010

Abstract excerpt

A major challenge in oncology is the development of chemoresistance. This often occurs as cancer progresses and malignant cells acquire mechanisms to resist insults that would normally induce apoptosis. The onset of androgen independence in advanced prostate cancer is a prime example of this phenomenon. Overexpression of the pro-survival/anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1 are hallmarks of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cell death mechanisms and regulation
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20298153
DOI: 10.2174/138945010791170888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemosensitization of Prostate Cancer by Modulating Bcl-2 Family ProteinsPMID 20298153Read ↗

Attacking cancer's Achilles heel: antagonism of anti‐apoptotic <scp>BCL</scp>‐2 family membersSemantic proximity Read ↗

Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancerSemantic proximity Read ↗

Bcl-xL in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity.Semantic proximity Read ↗

Modulating the Bcl-2 Family of Apoptosis Suppressors for Potential Therapeutic Benefit in CancerSemantic proximity Read ↗

Targeting Bcl-2 Family Proteins: What, Where, When?Semantic proximity Read ↗

Signaling Pathways That Control Apoptosis in Prostate CancerSemantic proximity Read ↗

Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak.Semantic proximity Read ↗

Apoptosis evasion: The role of survival pathways in prostate cancer progression and therapeutic resistanceSemantic proximity Read ↗

Targeting the B-Cell Lymphoma/Leukemia 2 Family in CancerSemantic proximity Read ↗

Getting personal with prostate cancer: adding new pieces to an incomplete jigsaw puzzle.Semantic proximity Read ↗

Toward Targeting Antiapoptotic MCL-1 for Cancer TherapySemantic proximity Read ↗

Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenograftsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.