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Article

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).

The Journal of clinical investigation - 15 Apr 1997

Oelkers P, Kirby L C, Heubi J E, Dawson P A

Abstract excerpt

Primary bile acid malabsorption (PBAM) is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. The molecular basis of PBAM is unknown, and several conflicting mechanisms have been postulated. In this study, we cloned the human ileal Na+/bile acid cotransporter gene (SLC10A2) and...

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Identifiers

PMID: 9109432
DOI: 10.1172/JCI119355
PMCID: PMC508012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).PMID 9109432Read ↗

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Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identified variants linked to reduced expression.Semantic proximity Read ↗

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.Semantic proximity Read ↗

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