Article
Induction of colitis in cftr-/- mice results in bile duct injury.
American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2004
Blanco Paola G, Zaman Munir M, Junaidi Omer, Sheth Sunil, Yantiss Rhonda K, Nasser Imad A, Freedman Steven D
Abstract excerpt
It is unknown why some patients with inflammatory bowel disease develop primary sclerosing cholangitis. We have recently shown that patients with primary sclerosing cholangitis have an increased prevalence of mutations in the gene responsible for cystic fibrosis (CFTR) compared with individuals with inflammatory bowel disease alone. Our aim was to examine whether induction of colitis by oral dextran leads to bile...
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