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Article

Induction of colitis in cftr-/- mice results in bile duct injury.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2004

Blanco Paola G, Zaman Munir M, Junaidi Omer, Sheth Sunil, Yantiss Rhonda K, Nasser Imad A, Freedman Steven D

Abstract excerpt

It is unknown why some patients with inflammatory bowel disease develop primary sclerosing cholangitis. We have recently shown that patients with primary sclerosing cholangitis have an increased prevalence of mutations in the gene responsible for cystic fibrosis (CFTR) compared with individuals w...

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Source

Identifiers

PMID: 15064232
DOI: 10.1152/ajpgi.00452.2003

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15064232-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Induction of colitis in cftr-/- mice results in bile duct injury.PMID 15064232Read ↗

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Pathophysiological basis of liver disease in cystic fibrosis employing a DeltaF508 mouse model.Semantic proximity Read ↗

Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis.Semantic proximity Read ↗

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.Semantic proximity Read ↗

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Diet‐Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in MiceSemantic proximity Read ↗

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