Article
Mutations in carboxy-terminal part of E2 including PKR/eIF2alpha phosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b: their correlation with response to interferon monotherapy and viral load.
World journal of gastroenterology - 21 Jun 2006
Ukai Koji, Ishigami Masatoshi, Yoshioka Kentaro, Kawabe Naoto, Katano Yoshiaki, Hayashi Kazuhiko, Honda Takashi, Yano Motoyoshi, Goto Hidemi
Abstract excerpt
AIM: To study the amino acid substitutions in the carboxy (C)-terminal part of E2 protein and in the interferon (IFN) sensitivity determining region (ISDR) and their correlation with response to IFN and viral load in 85 hepatitis C virus (HCV)-1b-infected patients treated with IFN. METHODS: The C-terminal part of E2 (codons 617-711) including PKR/eIF2alpha phosphorylation homology domain (PePHD) and ISDR was...
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