Article
Functional Rescue of Inactivating Mutations of the Human Neurokinin 3 Receptor Using Pharmacological Chaperones.
International journal of molecular sciences - 21 Apr 2022
Anderson Ross C, Hanyroup Sharika, Song Yong Bhum, Mohamed-Moosa Zulfiah, van den Bout Iman, Schwulst Alexis C, Kaiser Ursula B, Millar Robert P, Newton Claire L
Abstract excerpt
G protein-coupled receptors (GPCRs) facilitate the majority of signal transductions across cell membranes in humans, with numerous diseases attributed to inactivating GPCR mutations. Many of these mutations result in misfolding during nascent receptor synthesis in the endoplasmic reticulum (ER), resulting in intracellular retention and degradation. Pharmacological chaperones (PCs) are cell-permeant small...
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