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Article

Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status.

Pharmacogenetics - 1 Oct 2003

Barclay Murray L, Sawyers Steven M, Begg Evan J, Zhang Mei, Roberts Rebecca L, Kennedy Martin A, Elliott John M

Abstract excerpt

Perhexiline is metabolized by CYP2D6 and has concentration-related hepatoxicity and peripheral neuropathy. The risk of toxicity is reduced using therapeutic drug monitoring. CYP2D6 genotyping before therapy may allow earlier appropriate dosing. This study aimed to determine whether assessment of CYP2D6 genotype in patients on perhexiline could predict accurately metabolizer status as determined by the perhexiline...

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Identifiers

PMID: 14515061
DOI: 10.1097/00008571-200310000-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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