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Article

Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose.

British journal of clinical pharmacology - 1 Aug 2002

Sallustio Benedetta C, Westley Ian S, Morris Raymond G

Abstract excerpt

AIMS: 1) To develop an estimate of oral clearance (CL(Px)/F) for the antianginal agent perhexiline based on the ratio of cis-OH-perhexiline metabolite/parent perhexiline plasma concentrations at steady-state (C(OHPx,ss)/C(Px,ss)). 2) To determine whether the ratio measured in the first fortnight of treatment (C(i)(OHPx)/C(i)(Px)) may be used to guide patient dosing with perhexiline, a drug with a narrow...

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Identifiers

PMID: 12207628
DOI: 10.1046/j.1365-2125.2002.01618.x
PMCID: PMC1874409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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