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Article

Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells.

Endocrinology - 1 Jul 2003

Simon Violaine, Robin Marie-Thérèse, Legrand Chantal, Cohen-Tannoudji Joëlle

Abstract excerpt

We previously reported that G protein-coupled receptor kinase (GRK) may contribute to beta-adrenergic receptor (beta-AR) uncoupling occurring just before parturition in rat uterine muscle (myometrium). To identify the GRK involved, we set up in this study a primary cell culture retaining the morphological and functional characteristics of myometrial tissue as well as the in vivo pattern of GRK expression (GRK2,...

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Share to Cyclic AMP-Dependent Protein Kinases
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth

Share to Mutagenesis

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Share to Protein Serine-Threonine Kinases

Share to Rats, Sprague-Dawley

Share to Receptors, Adrenergic, beta

Source

Identifiers

PMID: 12810562
DOI: 10.1210/en.2002-0138

Genes

GRK6
GRK5
GRK2
GRK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells.PMID 12810562Read ↗

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