Article
Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004
Papadopoulou Nikolleta, Chen Jing, Randeva Harpal S, Levine Michael A, Hillhouse Edward W, Grammatopoulos Dimitris K
Abstract excerpt
Activation of CRH receptors type 1 (CRH-R1) by CRH or urocortin (UCN) leads to stimulation of multiple G proteins with consequent effects on diverse signaling cascades in a tissue-specific manner. In human myometrium and human embryonic kidney (HEK)293 cells, binding of UCN to CRH-R1alpha receptors activates both the Gs and Gq, leading to activation of the adenylyl cyclase/protein kinase A (PKA) and the...
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