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Article

Genetics of rheumatoid arthritis: confronting complexity.

1 Jan 1999

Abstract excerpt

The genetic basis for rheumatoid arthritis (RA) is likely to be extremely complex. Even the role of MHC genes remains to be fully defined, and may involve interactive genetic effects. The difficulty of precisely defining the clinical phenotype, as well as underlying genetic heterogeneity, complicates the problem. In addition, stochastic genetic or physiologic events may contribute to the low penetrance of...

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PMID: 11094412
DOI: 10.1186/ar9

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