Article
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
The Journal of experimental medicine - 9 Jul 2007
Pasvolsky Ronit, Feigelson Sara W, Kilic Sara Sebnem, Simon Amos J, Tal-Lapidot Guy, Grabovsky Valentin, Crittenden Jill R, Amariglio Ninette, Safran Michal, Graybiel Ann M, Rechavi Gideon, Ben-Dor Shifra, Etzioni Amos, Alon Ronen
Abstract excerpt
Leukocyte and platelet integrins rapidly alter their affinity and adhesiveness in response to various activation (inside-out) signals. A rare leukocyte adhesion deficiency (LAD), LAD-III, is associated with severe defects in leukocyte and platelet integrin activation. We report two new LAD cases in which lymphocytes, neutrophils, and platelets share severe defects in beta(1), beta(2), and beta(3) integrin...
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