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Article

Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease

1 Jul 2003

Abstract excerpt

There is substantial evidence that excitotoxicity and oxidative damage may contribute to Huntington's disease (HD) pathogenesis. We examined whether the novel anti-oxidant compound BN82451 exerts neuroprotective effects in the R6/2 transgenic mouse model of HD. Oral administration of BN82451 significantly improved motor performance and improved survival by 15%. Oral administration of BN82451 significantly reduced...

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PMID: 12807446
DOI: 10.1046/j.1471-4159.2003.t01-1-01868.x

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