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Article

Hydroxyurea Treatment for Sickle Cell Disease

1 Jan 2002

Abstract excerpt

High fetal hemoglobin (HbF) levels inhibit the polymerization of sickle hemoglobin (HbS) and reduce the complications of sickle cell disease. Pharmacologic agents that can reverse the switch from gamma- to beta-chain synthesis--gama-globin chains characterize HbF, and sickle beta-globin chains are present in HbS--or selectively increase the proportion of adult erythroid precursors that maintain the ability to...

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 12806165
DOI: 10.1100/tsw.2002.295

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