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Article

Lessons from an LPS-deficient Neisseria meningitidis mutant.

Journal of endotoxin research - 1 Jan 2003

van der Ley Peter, Steeghs Liana

Abstract excerpt

In the pathogen Neisseria meningitidis, a completely LPS-deficient but viable mutant can be obtained by insertional inactivation of the lpxA gene, encoding UDP-GlcNAc acyltransferase required for the first step of lipid A biosynthesis. The expression and assembly of integral outer membrane proteins in the absence of LPS is largely unaffected. However, the expression of iron limitation-inducible, cell...

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Source

Identifiers

PMID: 12803887
DOI: 10.1179/096805103125001522

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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