Article
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Oncogene - 12 Jun 2003
Dammann Reinhard, Schagdarsurengin Undraga, Liu Limin, Otto Noreen, Gimm Oliver, Dralle Henning, Boehm Bernhard O, Pfeifer Gerd P, Hoang-Vu Cuong
Abstract excerpt
Recently, we have characterized the Ras association domain family 1A gene (RASSF1A) at the segment 3p21.3, which is frequently lost in variety of human cancers and epigenetically inactivated in many types of primary tumors, such as lung, breast, kidney, prostate and thyroid carcinomas. Here, we investigated the methylation status of the RASSF1A CpG island promoter in the pathogenesis of pancreatic cancer. RASSF1A...
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