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Article

MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.

PloS one - 4 Mar 2011

Clegg Nicola J, Couto Suzana S, Wongvipat John, Hieronymus Haley, Carver Brett S, Taylor Barry S, Ellwood-Yen Katharine, Gerald William L, Sander Chris, Sawyers Charles L

Abstract excerpt

MYC and phosphoinositide 3-kinase (PI3K)-pathway deregulation are common in human prostate cancer. Through examination of 194 human prostate tumors, we observed statistically significant co-occurrence of MYC amplification and PI3K-pathway alteration, raising the possibility that these two lesions cooperate in prostate cancer progression. To investigate this, we generated bigenic mice in which both activated human...

Topics

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Enzyme Activation
Neoplasm Invasiveness
Precancerous Conditions
Prostate
Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-akt

Proto-Oncogene Proteins c-myc

TOR Serine-Threonine Kinases

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Open in PubMed Open full text

Identifiers

PMID: 21394210
DOI: 10.1371/journal.pone.0017449
PMCID: PMC3048873

Genes

MYC
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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