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Article

Chaperone-like effect of the linker on the isolated C-terminal domain of rabbit muscle creatine kinase.

Biophysical journal - 8 Aug 2012

Chen Zhe, Chen Xiang-Jun, Xia Mengdie, He Hua-Wei, Wang Sha, Liu Huihui, Gong Haipeng, Yan Yong-Bin

Abstract excerpt

Intramolecular chaperones (IMCs), which are specific domains/segments encoded in the primary structure of proteins, exhibit chaperone-like activity against the aggregation of the other domains in the same molecule. In this research, we found that the truncation of the linker greatly promoted the thermal aggregation of the isolated C-terminal domain (CTD) of rabbit muscle creatine kinase (RMCK). Either the...

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Identifiers

PMID: 22947872
DOI: 10.1016/j.bpj.2012.07.002
PMCID: PMC3414881

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