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Article

Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Feb 2012

Joseph Raji E, Ginder Nathaniel D, Hoy Julie A, Nix Jay C, Fulton D Bruce, Honzatko Richard B, Andreotti Amy H

Abstract excerpt

The crystal structure of the interleukin-2 tyrosine kinase Src homology domain (Itk SH2) is described and it is found that unlike in studies of this domain using NMR spectroscopy, cis-trans-prolyl isomerization is not readily detected in the crystal structure. Based on similarities between the Itk SH2 crystal form and the cis form of the Itk SH2 NMR structure, it is concluded that it is likely that the prolyl...

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Identifiers

PMID: 22297986
DOI: 10.1107/S1744309111049761
PMCID: PMC3274390

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