Article
The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 May 2003
Rodríguez-Esparragón Francisco, Hernández-Perera Octavio, Rodríguez-Pérez José C, Anábitarte Aránzazu, Díaz-Cremades Juan M, Losada Antonio, Fiuza Dolores, Hernández Enrique, Yunis Carla, Ferrario Carlos M
Abstract excerpt
The C677T transition of methylenetetrahydrofolate reductase (MTHFR) gene causes a moderate increase in total plasma homocysteine (tHcy). We studied the effect of MTHFR TT homozygosity and mild hyperhomocysteinemia on arterial hypertension. Normotensive controls (n = 223) and hypertensive subjects (n = 235) were matched for age, gender, and history of cardiovascular disease. Homocysteine levels were measured by a...
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