Article
Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma.
Annals of surgical oncology - 1 Oct 2009
Yashiro Masakazu, Inoue Toru, Nishioka Nobuaki, Matsuoka Tasuku, Boland C Richard, Hirakawa Kosei
Abstract excerpt
BACKGROUND: Combined treatment with 5-fluorouracil and cisplatin (FP chemotherapy) is an effective neoadjuvant regimen for gastric carcinoma. However, it is ineffective in half of all patients. This study tests the hypothesis that genetic markers might identify those patients with gastric cancer who would respond to neoadjuvant FP chemotherapy. MATERIALS AND METHODS: A total of 23 patients with gastric carcinoma...
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