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Article

TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2012

Cheng Lai Ling, Itahana Yoko, Lei Zheng Deng, Chia Na-Yu, Wu Yonghui, Yu Yingnan, Zhang Shen Li, Thike Aye Aye, Pandey Anuradha, Rozen Steve, Voorhoeve Pieter Mathijs, Yu Qiang, Tan Puay Hoon, Bay Boon Huat, Itahana Koji, Tan Patrick

Abstract excerpt

PURPOSE: DZNep (3-deazaneplanocin A) depletes EZH2, a critical component of polycomb repressive complex 2 (PRC2), which is frequently deregulated in cancer. Despite exhibiting promising anticancer activity, the specific genetic determinants underlying DZNep responsiveness in cancer cells remain largely unknown. We sought to determine molecular factors influencing DZNep response in gastric cancer. EXPERIMENTAL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22675170
DOI: 10.1158/1078-0432.CCR-12-0036

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USP10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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