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Article

Fluorine-19 nuclear magnetic resonance as a probe of the solution structure of mutants of 5-fluorouracil-substituted Escherichia coli valine tRNA.

Journal of molecular biology - 20 Oct 1992

Chu W C, Feiz V, Derrick W B, Horowitz J

Abstract excerpt

In order to utilize 19F nuclear magnetic resonance (NMR) to probe the solution structure of Escherichia coli tRNAVal labeled by incorporation of 5-fluorouracil, we have assigned its 19F spectrum. We describe here assignments made by examining the spectra of a series of tRNAVal mutants with nucleotide substitutions for individual 5-fluorouracil residues. The result of base replacements on the structure and...

Topics

Acylation
Anticodon
Base Sequence
Escherichia coli
Fluorine
Fluorouracil
Kinetics
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Mutation
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Bacterial

RNA, Transfer, Val

Solutions

Transcription, Genetic

Source

Identifiers

PMID: 1279180
DOI: 10.1016/0022-2836(92)90528-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1279180-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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