Modulation of conformational changes in helix 69 mutants by pseudouridine modifications.

doi:10.1016/j.bpc.2015.03.001

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Article

Modulation of conformational changes in helix 69 mutants by pseudouridine modifications.

Biophysical chemistry - 1 Jan 2000

Jiang Jun, Kharel Daya Nidhi, Chow Christine S

Abstract excerpt

Centrally located at the ribosomal subunit interface and mRNA tunnel, helix 69 (H69) from 23S rRNA participates in key steps of translation. Ribosome activity is influenced by three pseudouridine modifications, which modulate the structure and conformational behavior of H69. To understand how H69 is affected by the presence of pseudouridine in combination with sequence changes, the biophysical properties of...

Topics

Escherichia coli
Escherichia coli Proteins
Models, Molecular
Mutation
Nucleic Acid Conformation
Pseudouridine
RNA

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Identifiers

PMID: 25800680
DOI: 10.1016/j.bpc.2015.03.001
PMCID: PMC4414897

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