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Article

The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium.

Experimental cell research - 1 Apr 2009

DeRosa Adam M, Meşe Gülistan, Li Leping, Sellitto Caterina, Brink Peter R, Gong Xiaohua, White Thomas W

Abstract excerpt

Mutations in Connexin50 (Cx50) cause cataracts in both humans and mice. The mechanism(s) behind how mutated connexins lead to a variety of cataracts have yet to be fully elucidated. Here, we tested whether the cataract inducing Cx50-S50P mutant interacts with wild-type Connexin43 (Cx43) to form mixed channels with attenuated function. Using dual whole-cell voltage clamp, immunofluorescent microscopy and in situ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19331825
DOI: 10.1016/j.yexcr.2009.01.017
PMCID: PMC2670955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium.PMID 19331825Read ↗

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