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Article

Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma.

Cancer genetics - 1 May 2012

Hosur Vishnu, Kavirayani Anoop, Riefler Jennifer, Carney Lisa M B, Lyons Bonnie, Gott Bruce, Cox Gregory A, Shultz Leonard D

Abstract excerpt

Although researchers have yet to establish a link between muscular dystrophy (MD) and sarcomas in human patients, literature suggests that the MD genes dystrophin and dysferlin act as tumor suppressor genes in mouse models of MD. For instance, dystrophin-deficient mdx and dysferlin-deficient A/J mice, models of human Duchenne MD and limb-girdle MD type 2B, respectively, develop mixed sarcomas with variable...

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Source

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Identifiers

PMID: 22682622
DOI: 10.1016/j.cancergen.2012.03.005
PMCID: PMC3372852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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