Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What We Have Here Is a Failure to Communicate: Interleukin-12 / Interferon-gamma Axis Defects and Mendelian Susceptibility to Mycobacterial Disease.

The journal of allergy and clinical immunology. In practice - 1 Jul 2026

Johnston Alicia Μ, Rider Nicholas L, Freeman Alexandra F, Holland Steven M, Orange Jordan S, Platt Craig D, Anglero Andrea Carlo, Tsoulis Michael, Zinn Daniel, Passarelli Patrick, Shaker Marcus

Abstract excerpt

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare group of immunodeficiencies with high mortality characterized by a failure of communication between phagocytic cells and their regulatory/support networks. The objective of this article was to review key aspects of MSMD management. A defective IL-12/IFN-γ circuit can result in overwhelming intracellular infection, leading to lymphadenopathy,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-12

Share to Mycobacterium Infections

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 41786143
DOI: 10.1016/j.jaip.2026.02.026
PMCID: PMC13001684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What We Have Here Is a Failure to Communicate: Interleukin-12 / Interferon-gamma Axis Defects and Mendelian Susceptibility to Mycobacterial Disease.PMID 41786143Read ↗

Mendelian susceptibility to mycobacterial disease: IFN-γ-driven immunity collapse underlies heterogeneous infections.Semantic proximity Read ↗

Laboratory evaluation of the IFN-γ circuit for the molecular diagnosis of Mendelian susceptibility to mycobacterial disease.Semantic proximity Read ↗

IL12Rβ1 defect presenting with massive intra-abdominal lymphadenopathy due to Mycobacterium intracellulare infection.Semantic proximity Read ↗

Mendelian Susceptibility to Mycobacterial Disease with Signal Peptide Peptidase-like 2A (SPPL2A) Deficiency: A Case Report.Semantic proximity Read ↗

Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.Semantic proximity Read ↗

Mendelian susceptibility to mycobacterial disease: recent discoveries.Semantic proximity Read ↗

Clinical recommendations for diagnosis and management of Mendelian susceptibility to mycobacterial disease in resource-limited settingsSemantic proximity Read ↗

Impact of molecular diagnosis on treating Mendelian susceptibility to mycobacterial diseases.Semantic proximity Read ↗

Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases.Semantic proximity Read ↗

Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features.Semantic proximity Read ↗

Genetic, immunologic, and clinical features of 830 patients with Mendelian susceptibility to mycobacterial diseases (MSMD): A systematic review.Semantic proximity Read ↗

Human host genetic factors in nontuberculous mycobacterial infection: lessons from single gene disorders affecting innate and adaptive immunity and lessons from molecular defects in interferon-gamma-dependent signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.