Reduction in mortalin level by its antisense expression causes senescence‐like growth arrest in human immortalized cells

Abstract excerpt

BACKGROUND: Human normal cells have active p53 and pRB tumor suppressor pathways and undergo telomere shortening at each cell division. When immortalized, these exhibit functional inactivation of one or both tumor suppressor pathways and activation of telomere-maintaining mechanisms. Regulation of immortalization promoting molecular pathways by other genes is poorly understood and is an essential component of...

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