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Article

Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.

International journal of cancer - 15 Oct 2011

Lu Wen-Jing, Lee Nikki P, Kaul Sunil C, Lan Feng, Poon Ronnie T P, Wadhwa Renu, Luk John M

Abstract excerpt

Stress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found that the level of mortalin expression has significant correlation with human hepatocellular carcinoma (HCC) malignancy and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21165951
DOI: 10.1002/ijc.25857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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